ZFIN ID: ZDB-GENE-041210-21
Gene Name: transcription factor EC
Gene Symbol: tfec    Nomenclature History

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Previous Name: si:ch211-238e6.5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have protein dimerization activity. Involved in definitive hemopoiesis; hematopoietic stem cell homeostasis; and hematopoietic stem cell proliferation. Is expressed in several structures, including extension; eye; immature eye; intermediate cell mass of mesoderm; and neural crest. Orthologous to human TFEC (transcription factor EC).
Genome Resources: Alliance (1),  Gene:556894 (1),  Ensembl(GRCz11):ENSDARG00000098745 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ba6 Small Deletion Exon 7 Unknown CRISPR
sa30378 Point Mutation Unknown Premature Stop ENU
ug103 Small Deletion Exon 3 Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tfec 1
CRISPR2-tfec 1
DISEASE ASSOCIATED WITH tfec HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tfec VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic stem cell homeostasis (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR021802 MiT/TFE transcription factors, C-terminal
Domain IPR031867 MiT/TFE transcription factors, N-terminal
Family IPR024101 Transcription factor EC
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tfec
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.7tfec:EGFP) tfec EGFP Danio rerio 2 2
Tg(-2.7tfec:GAL4-VP16) tfec GAL4VP16 Danio rerio 1 1
Tg(4xUAS:tfec) UAS tfec Danio rerio 1 1
MARKER RELATIONSHIPS
tfec Contained in: [BAC] CH211-238E6 (1)
tfec Encodes: [cDNA] MGC:136250 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001030105 (1) 1428 nt
Genomic GenBank:BX470140 (1) 148136 nt
Select Tool
Polypeptide UniProtKB:A0A0R4IX50 (1) 396 aa
Sequence Information (all 20)
ORTHOLOGY for tfec ( Chr: 4 )
CITATIONS (32)