Gene

socs2

ID
ZDB-GENE-041210-171
Name
suppressor of cytokine signaling 2
Symbol
socs2 Nomenclature History
Previous Names
  • si:dkey-202b22.1
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of cell growth. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With socs2 Human Ortholog
No data available
Associated With socs2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR001496 SOCS box domain
Domain IPR035862 SOCS2, SH2 domain
Family IPR028410 Suppressor of cytokine signalling 2
Homologous_superfamily IPR036036 SOCS box-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length SH2 domain SH2 domain superfamily SOCS2, SH2 domain SOCS box domain SOCS box-like domain superfamily Suppressor of cytokine signalling 2
UniProtKB:B0EVP5 197
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations