ZFIN ID: ZDB-GENE-041210-167
Gene Name: plakophilin 2
Gene Symbol: pkp2    Nomenclature History

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Previous Name: si:ch211-11c20.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and protein kinase C binding activity. Involved in desmosome organization and heart looping. Predicted to localize to several cellular components, including adherens junction; intercalated disc; and intermediate filament. Is expressed in epidermis; heart; and neuroepithelial cell. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2).
Genome Resources: Alliance (1),  Gene:568060 (1),  Ensembl(GRCz11):ENSDARG00000023026 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pkp2 N/A 1
DISEASE ASSOCIATED WITH pkp2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arrhythmogenic right ventricular dysplasia 9 Alliance Arrhythmogenic right ventricular dysplasia 9 609040
DISEASE ASSOCIATED WITH pkp2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process desmosome organization (more)
Cellular Component adherens junction (more)
Molecular Function alpha-catenin binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pkp2-202 (1)    Ensembl 1740
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pkp2 No data available
MARKER RELATIONSHIPS
pkp2 Contained in: [BAC] CH211-11C20 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001113433 (1) 2824 nt
Genomic GenBank:BX001012 (1) 158481 nt
Select Tool
Polypeptide UniProtKB:B0BF33 (1) 815 aa
Sequence Information (all 10)
ORTHOLOGY for pkp2 ( Chr: 4 )
CITATIONS (18)