ZFIN ID: ZDB-GENE-041210-132
Gene Name: aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2
Gene Symbol: akr1b1.2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:dkey-180p18.9, zgc:153855

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have alditol:NADP+ 1-oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B).
Genome Resources: Alliance (1),  Gene:553452 (1),  Ensembl(GRCz11):ENSDARG00000045598 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138896]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024431Tg Transgenic Insertion Unknown Unknown DNA
PHENOTYPE No data available
DISEASE ASSOCIATED WITH akr1b1.2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH akr1b1.2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component cytosol (more)
Molecular Function oxidoreductase activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR018170 Aldo/keto reductase, conserved site
Family IPR020471 Aldo/keto reductase
Domain IPR023210 NADP-dependent oxidoreductase domain
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA akr1b1 (1 of many)-201 (1)    Ensembl 1592
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM akr1b1.2 No data available
MARKER RELATIONSHIPS
akr1b1.2 Contained in: [BAC] DKEY-180P18 (1) (order this)
akr1b1.2 Encodes: [EST] IMAGE:7138896 (1)
[cDNA] MGC:136460 (1), MGC:153855 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001077247 (1)
Genomic GenBank:BX571796 (1) 130699 bp
Select Tool
Polypeptide UniProtKB:Q502L9 (1) 346 aa
Sequence Information (all 22)
ORTHOLOGY for akr1b1.2 ( Chr: 4 )
CITATIONS (22)