Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-041203-2
Gene Name: forkhead box P2
Gene Symbol: foxp2
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
  brain, caudal tuberculum, central nervous system, cerebellum (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 12 genotypes
Alleles: sa11787, sa13041, zc82, zc83, zc84
PHENOTYPE
Data: Fig. 4 from Xing et al., 2012
Observed in: central nervous system development

Phenotype of Human Orthologue OMIM Phenotype ID
Speech-language disorder-1 602081
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Molecular Function DNA binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001766 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR015880 (1)
  • InterPro:IPR018122 (1)
  • PROSITE:PS00658 (1)
  • PROSITE:PS50039 (1)
  • Pfam:PF00250 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA foxp2-001 (1) 2927
    foxp2-003 (1) 2485
    mRNA foxp2-004 (1) 602
    ncRNA foxp2-005 (1) 979
    mRNA foxp2-007 (1) 2725
    foxp2-008 (1) 2376
    ncRNA foxp2-009 (1) 573
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM foxp2
    Tg(foxp2.A1:EGFP), Tg(foxp2.A2:EGFP), Tg(foxp2.A2:EGFP-CAAX), Tg(foxp2.A2:GAL4-VP16,myl7:EGFP), Tg(foxp2.A:EGFP) (all 7) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    foxp2 Contained in: [BAC] CH211-262N1 (1) (order this), DKEY-112E7 (1), DKEY-116L11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001030082 (1) 2776 bp
    Genomic GenBank:CR356233 (1) 146900 bp
    Select Tool
    Polypeptide UniProtKB:Q4JNX5 (1) 697 aa
    Sequence Clusters UniGene:106317 (1)
    Sequence Information (all 13)
    OTHER foxp2 GENE PAGES
  • Gene:555242 (1)
  • VEGA:OTTDARG00000018204 (1)
  • Ensembl(Zv9):ENSDARG00000005453 (1)
  • MAPPING INFORMATION
    Chr: 4 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish foxp2 4  
    Human FOXP2 7 (7q31)
  • OMIM:605317
  • Gene:93986
  • Mouse Foxp2 6 ( 6.49 cM)
  • MGI:2148705
  • Gene:114142
  • CITATIONS (24)