ZFIN ID: ZDB-GENE-041124-3
Gene Name: exostosin glycosyltransferase 2
Gene Symbol: ext2    Nomenclature History

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Previous Names: ext2a (1), dackel, dak, fc14g07, wu:fc14g07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and acetylglucosaminyltransferase activity. Involved in several processes, including animal organ development; generation of neurons; and proteoglycan biosynthetic process. Predicted to localize to Golgi apparatus. Is expressed in nervous system and pectoral fin musculature. Used to study hereditary multiple exostoses. Orthologous to human EXT2 (exostosin glycosyltransferase 2).
Genome Resources: Alliance (1),  Gene:493780 (1),  Ensembl(GRCz11):ENSDARG00000056648 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Lee et al., 2004
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE
Data: 55 figures from 19 publications
Observed in:
DISEASE ASSOCIATED WITH ext2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary multiple exostoses Alliance Exostoses, multiple, type 2 133701
Seizures, scoliosis, and macrocephaly syndrome 616682
DISEASE ASSOCIATED WITH ext2 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
hereditary multiple exostoses ext2to273b/to273b standard conditions Wiweger et al., 2014
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ext2-201 (1)    Ensembl 3172
ncRNA ext2-002 (1)    Ensembl 784
ext2-003 (1)    Ensembl 667
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ext2
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:ext2-2A-TagRFP,myl7:EGFP) hsp70lmyl7 EGFPext2TagRFP Danio rerio 1 2
MARKER RELATIONSHIPS
ext2 Contained in: [BAC] CH211-107P11 (1)
ext2 Encodes: [EST] fc14g07
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001008400 (1) 3195 nt
Genomic GenBank:BX510305 (1) 156938 nt
Select Tool
Polypeptide UniProtKB:F1QUC2 (1) 719 aa
Sequence Information (all 10)
ORTHOLOGY for ext2 ( Chr: 7 )
CITATIONS (56)