Gene
ncf4
- ID
- ZDB-GENE-041124-1
- Name
- neutrophil cytosolic factor 4
- Symbol
- ncf4 Nomenclature History
- Previous Names
-
- p40phox (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide metabolic process. Predicted to localize to NADPH oxidase complex. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease cytochrome b-positive type III. Orthologous to human NCF4 (neutrophil cytosolic factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu789 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive chronic granulomatous disease 3 | Alliance | Chronic granulomatous disease 3, autosomal recessive | 613960 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000270 | PB1 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001683 | Phox homology |
| Domain | IPR034853 | Neutrophil cytosol factor P40, PB1 domain |
| Domain | IPR034912 | Neutrophil cytosol factor 4, PX domain |
| Domain | IPR035541 | Neutrophil cytosol factor P40, SH3 domain |
| Family | IPR000919 | Neutrophil cytosol factor P40 |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036871 | PX domain superfamily |
Domain Details Per Protein
| Protein | Length | Neutrophil cytosol factor 4, PX domain | Neutrophil cytosol factor P40 | Neutrophil cytosol factor P40, PB1 domain | Neutrophil cytosol factor P40, SH3 domain | PB1 domain | Phox homology | PX domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LUW2
|
355 |
Interactions and Pathways
No data available
Plasmids
No data available