Gene
aicda
- ID
- ZDB-GENE-041122-2
- Name
- activation-induced cytidine deaminase
- Symbol
- aicda Nomenclature History
- Previous Names
-
- aid (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables cytidine deaminase activity. Acts upstream of or within somatic cell DNA recombination. Predicted to be active in cytoplasm and nucleus. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Rai et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency with hyper-IgM type 2 | Alliance | Immunodeficiency with hyper-IgM, type 2 | 605258 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | APOBEC/CMP deaminase, zinc-binding | APOBEC Cytidine Deaminase | APOBEC-like, N-terminal | Cytidine and deoxycytidylate deaminase domain | Cytidine deaminase-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5YF88 | InterPro | 210 |
Interactions and Pathways
No data available
Plasmids
No data available