Gene

aicda

ID

ZDB-GENE-041122-2

Name

activation-induced cytidine deaminase

Symbol

aicda Nomenclature History

Previous Names

aid (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Exhibits cytidine deaminase activity. Involved in somatic cell DNA recombination. Predicted to localize to cytoplasm and nucleus. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase).

Genome Resources

Note

None

Expression

All Expression Data

4 figures from Rai et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aicda Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency with hyper-IgM type 2	Alliance	Immunodeficiency with hyper-IgM, type 2	605258

Associated With aicda Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR016192	APOBEC/CMP deaminase, zinc-binding
Domain	IPR002125	Cytidine and deoxycytidylate deaminase domain
Homologous_superfamily	IPR016193	Cytidine deaminase-like