ZFIN ID: ZDB-GENE-041121-9
Gene Name: guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
Gene Symbol: gna11b    Nomenclature History

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Previous Names: G11-1 (1), Galpha 11a (1), wu:fb12d06, zgc:101761

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; entrainment of circadian clock; and phototransduction, visible light. Predicted to localize to the heterotrimeric G-protein complex and photoreceptor outer segment. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Is expressed in barbel; brain; gill; lip; and sensory system. Orthologous to human GNA11 (G protein subunit alpha 11).
Genome Resources: Alliance (1),  Gene:493613 (1),  Ensembl(GRCz11):ENSDARG00000053326 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023778Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gna11b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant hypocalcemia 2 Alliance Hypocalcemia, autosomal dominant 2 615361
    familial hypocalciuric hypercalcemia 2 Alliance Hypocalciuric hypercalcemia, type II 145981
    DISEASE ASSOCIATED WITH gna11b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process entrainment of circadian clock (more)
    Cellular Component membrane (more)
    Molecular Function G-protein beta/gamma-subunit complex binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000654 G-protein alpha subunit, group Q
    Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gna11b No data available
    MARKER RELATIONSHIPS
    gna11b Encodes: [EST] fb12d06
    [cDNA] MGC:101761 (1), MGC:191353 (1)
    gna11b Has Artifact: [EST] fc80c01 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007773 (1) 2437 bp
    Genomic GenBank:CU929198 (1) 84443 bp
    Select Tool
    Polypeptide UniProtKB:Q5RKP9 (1) 359 aa
    Sequence Information (all 17)
    ORTHOLOGY for gna11b ( Chr: 2 )
    CITATIONS (26)