ZFIN ID: ZDB-GENE-041114-75
Gene Name: corticotropin releasing hormone b
Gene Symbol: crhb    Nomenclature History

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Previous Names: CRF (1), crh1b, crh, zgc:101864

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have hormone activity. Involved in several processes, including melanosome localization; regulation of hematopoietic stem cell differentiation; and response to immobilization stress. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in obesity and panic disorder. Is expressed in several structures, including brain; eye; gill; post-vent region; and testis. Orthologous to human CRH (corticotropin releasing hormone).
Genome Resources: Alliance (1),  Gene:492507 (1),  Ensembl(GRCz11):ENSDARG00000027657 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct862 Insertion Unknown Unknown CRISPR
la014553Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022938Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-crhb 1
    MO1-crhb N/A 2
    DISEASE ASSOCIATED WITH crhb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH crhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to immobilization stress (more)
    Cellular Component extracellular region (more)
    Molecular Function hormone activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000187 Corticotropin-releasing factor
    Family IPR003620 Urocortin/corticotropin-releasing factor
    Conserved_site IPR018446 Corticotropin-releasing factor conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crhb-201 (1)    Ensembl 1079
    crhb-202 (1)    Ensembl 931
    crhb-203 (1)    Ensembl 420
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crhb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(crhb:TagRFP) crhb TagRFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    crhb Contained in: [BAC] CH211-125L9 (1)
    crhb Encodes: [cDNA] MGC:101864 (1), MGC:192053 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007379 (1) 1096 bp
    Genomic GenBank:CR354424 (1) 156999 bp
    Select Tool
    Polypeptide UniProtKB:A4U7I6 (1) 162 aa
    Sequence Information (all 19)
    ORTHOLOGY for crhb ( Chr: 24 )
    CITATIONS (152)