ZFIN ID: ZDB-GENE-041114-22
Gene Name: lysine methyltransferase 5B
Gene Symbol: kmt5b    Nomenclature History

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Previous Names: suv420h1 (1), wu:fb97g06, wu:fi57g03, zgc:103527

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H4-K20 specific). Involved in histone H4-K20 methylation and regulation of growth. Predicted to localize to the chromosome and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 51. Orthologous to human KMT5B (lysine methyltransferase 5B).
Genome Resources: Alliance (1),  Gene:572849 (1),  Ensembl(GRCz11):ENSDARG00000041081 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103527]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18386 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23293 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36641 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36642 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kmt5b N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kmt5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant mental retardation 51 Alliance Mental retardation, autosomal dominant 51 617788
    DISEASE ASSOCIATED WITH kmt5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone H4-K20 methylation (more)
    Cellular Component chromosome (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001214 SET domain
    Family IPR025790 Histone-lysine N-methyltransferase, Suvar4-20
    Family IPR039977 Histone-lysine N-methyltransferase KMT5B/KMT5C/SET9
    Homologous_superfamily IPR041938 Histone-lysine N-methyltransferase, N-terminal domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kmt5b-201 (1)    Ensembl 4073
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kmt5b No data available
    MARKER RELATIONSHIPS
    kmt5b Contained in: [BAC] CH211-286F6, DKEY-12E7 (1) (order this)
    kmt5b Encodes: [EST] fb97g06 (1), fi57g03 (1)
    [cDNA] MGC:103527 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007337 (1) 2821 bp
    Genomic GenBank:BX548052 146410 bp
    Select Tool
    Polypeptide UniProtKB:Q5U3H2 (1) 808 aa
    Sequence Information (all 19)
    ORTHOLOGY for kmt5b ( Chr: 18 )
    CITATIONS (28)