Gene

ube3a

ID

ZDB-GENE-041114-190

Name

ubiquitin protein ligase E3A

Symbol

ube3a Nomenclature History

Previous Names

im:7140733
zgc:92173 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and regulation of ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7140733 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ube3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Angelman syndrome	Alliance	Angelman syndrome	105830

Associated With ube3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000569	HECT domain
Domain	IPR032353	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain
Family	IPR017134	Ubiquitin-protein ligase E3A
Family	IPR044611	Ubiquitin-protein ligase E3A/B/C-like
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR042556	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily

Domain Details Per Protein

Protein	Length	HECT domain	HECT, E3 ligase catalytic domain	Ubiquitin-protein ligase E3A	Ubiquitin-protein ligase E3A/B/C-like	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily
UniProtKB:Q5U398 InterPro	857

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ube3a-201 (1) Ensembl	Ensembl	4,104 nt	Select Tool ZFIN BLAST
mRNA	ube3a-203 (1) Ensembl	Ensembl	3,858 nt	Select Tool ZFIN BLAST
ncRNA	ube3a-002 (1) Ensembl	Ensembl	865 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations