Gene

ube3a

ID
ZDB-GENE-041114-190
Name
ubiquitin protein ligase E3A
Symbol
ube3a Nomenclature History
Previous Names
  • im:7140733
  • zgc:92173 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ligase activity and ubiquitin protein ligase activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to localize to cytosol; nucleus; and proteasome complex. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ube3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Angelman syndrome Alliance Angelman syndrome 105830
Associated With ube3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000569 HECT domain
Domain IPR032353 Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain
Family IPR017134 Ubiquitin-protein ligase E3A
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR042556 Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily
Domain Details Per Protein
Protein Length HECT domain HECT, E3 ligase catalytic domain Ubiquitin-protein ligase E3A Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily
UniProtKB:A9JT10 766
UniProtKB:C5IG51 119
UniProtKB:Q5U398 857
UniProtKB:F1R4B5 857
UniProtKB:A0A2R8RIT0 766
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations