ZFIN ID: ZDB-GENE-041114-174
Gene Name: CLN3 lysosomal/endosomal transmembrane protein, battenin
Gene Symbol: cln3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:92244 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in axonogenesis; lysosome organization; and negative regulation of neuron apoptotic process. Predicted to localize to the lysosome. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Is expressed in brain; central nervous system; cerebellum; and midbrain hindbrain boundary. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin).
Genome Resources: Alliance (1),  Gene:492340 (1),  Ensembl(GRCz11):ENSDARG00000037865 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92244]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20092 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cln3 N/A 1
    MO2-cln3 N/A 1
    DISEASE ASSOCIATED WITH cln3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neuronal ceroid lipofuscinosis 3 Alliance Ceroid lipofuscinosis, neuronal, 3 204200
    DISEASE ASSOCIATED WITH cln3 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    neuronal ceroid lipofuscinosis 3 TL + MO1-cln3 standard conditions Wager et al., 2016
    TL + MO2-cln3 standard conditions Wager et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR003492 Batten's disease protein Cln3
    Family IPR018460 Batten's disease protein Cln3, subgroup
    Homologous_superfamily IPR036259 MFS transporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cln3-201 (1)    Ensembl 1873
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cln3 No data available
    MARKER RELATIONSHIPS
    cln3 Contained in: [BAC] CH211-198P11 (1)
    cln3 Encodes: [cDNA] MGC:92244 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007306 (1) 1858 nt
    Genomic GenBank:BX537342 (1) 195436 nt
    Select Tool
    Polypeptide UniProtKB:Q5U392 (1) 446 aa
    Sequence Information (all 8)
    ORTHOLOGY for cln3 ( Chr: 3 )
    CITATIONS (24)