ZFIN ID: ZDB-GENE-041114-172
Gene Name: PR domain containing 12b
Gene Symbol: prdm12b    Nomenclature History

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Previous Name: zgc:101606

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase binding activity. Involved in hemopoiesis; negative regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron specification. Predicted to localize to nucleus. Is expressed in several structures, including basal plate midbrain region; hindbrain neural keel; midbrain neural keel; nervous system; and neurogenic placode. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12).
Genome Resources: Alliance (1),  Gene:492816 (1),  Ensembl(GRCz11):ENSDARG00000007430 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9887 Point Mutation Splice Junction Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um318 Indel Exon 1 Frameshift, Premature Stop CRISPR
    um319 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prdm12b
    1
    CRISPR2-prdm12b
    1
    CRISPR3-prdm12b
    1
    CRISPR4-prdm12b
    1
    CRISPR5-prdm12b 1
    MO1-prdm12b N/A 2
    MO2-prdm12b N/A 1
    MO3-prdm12b N/A 1
    MO4-prdm12b N/A 1
    MO5-prdm12b N/A 1
    DISEASE ASSOCIATED WITH prdm12b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary sensory and autonomic neuropathy type 8 Alliance Neuropathy, hereditary sensory and autonomic, type VIII 616488
    DISEASE ASSOCIATED WITH prdm12b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription by RNA polymerase II (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prdm12b No data available
    MARKER RELATIONSHIPS
    prdm12b Encodes: [cDNA] MGC:101606 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007457 (1)
    Polypeptide UniProtKB:Q5U3V3 (1) 366 aa
    Sequence Information (all 9)
    ORTHOLOGY for prdm12b ( Chr: 5 )
    CITATIONS (28)