ZFIN ID: ZDB-GENE-041114-167
Gene Name: guanine nucleotide binding protein (G protein), beta polypeptide 4b
Gene Symbol: gnb4b    Nomenclature History

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Previous Name: zgc:101614

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to be involved in signal transduction. Is expressed in head; neuromast; and posterior lateral line primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate F. Orthologous to human GNB4 (G protein subunit beta 4).
Genome Resources: Alliance (1),  Gene:492811 (1),  Ensembl(GRCz11):ENSDARG00000115383 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21983 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21984 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gnb4b N/A 3
    MO2-gnb4b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnb4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease dominant intermediate F Alliance Charcot-Marie-Tooth disease, dominant intermediate F 615185
    DISEASE ASSOCIATED WITH gnb4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component cytoplasm (more)
    Molecular Function G-protein gamma-subunit binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnb4b No data available
    MARKER RELATIONSHIPS
    gnb4b Encodes: [cDNA] MGC:101614 (1), MGC:191805 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007452 (1) 2245 nt
    Genomic GenBank:CABZ01039270 (1)
    Polypeptide UniProtKB:A0A2R8RKX9 (1) 340 aa
    Sequence Information (all 32)
    ORTHOLOGY for gnb4b ( Chr: 11 )
    CITATIONS (16)