ZFIN ID: ZDB-GENE-041114-13
Gene Name: interferon regulatory factor 1b
Gene Symbol: irf1b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: irf11 (2), irf1 (1), sb:eu922, zgc:103566

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of defense response to virus and response to virus. Localizes to nucleus. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1).
Genome Resources: Alliance (1),  Gene:792160 (1), 
GENE EXPRESSION
All Expression Data: 10 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu922]
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb81 Indel Exon 1 Unknown CRISPR
ihb85 Insertion Unknown Unknown
ihb112 Indel Exon 1 Splice Site CRISPR
la014106Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37387 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-irf1b 2
    MO1-irf1b N/A 1
    MO2-irf1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH irf1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
    stomach cancer Alliance Gastric cancer, somatic 613659
    Myelodysplastic syndrome, preleukemic
    Myelogenous leukemia, acute
    DISEASE ASSOCIATED WITH irf1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of defense response to virus (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irf1b-201 (1)    Ensembl 1894
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irf1b No data available
    MARKER RELATIONSHIPS
    irf1b Contained in: [BAC] CH211-25G7 (1)
    irf1b Encodes: [EST] eu922 (1)
    [cDNA] MGC:103566 (1), MGC:192360 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205747 (1) 1967 nt
    Genomic GenBank:CU302316 (1) 166312 nt
    Select Tool
    Polypeptide UniProtKB:B5DDP2 (1) 287 aa
    Sequence Information (all 20)
    ORTHOLOGY for irf1b ( Chr: 21 )
    CITATIONS (57)