Gene

trip12

ID
ZDB-GENE-041111-262
Name
thyroid hormone receptor interactor 12
Symbol
trip12 Nomenclature History
Previous Names
  • im:7149446
  • si:ch211-272f3.4 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; negative regulation of nitrogen compound metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to localize to nucleoplasm. Is expressed in myotome. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trip12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Clark-Baraitser syndrome Alliance Mental retardation, autosomal dominant 49 617752
Associated With trip12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000569 HECT domain
Domain IPR004170 WWE domain
Domain IPR018123 WWE domain, subgroup
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR037197 WWE domain superfamily
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold HECT domain HECT, E3 ligase catalytic domain WWE domain WWE domain, subgroup WWE domain superfamily
UniProtKB:F1RCR6 2026
UniProtKB:E9QHK4 32
UniProtKB:A0A2R8Q6F8 2111
UniProtKB:F1Q529 2053
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations