Gene
trip12
- ID
- ZDB-GENE-041111-262
- Name
- thyroid hormone receptor interactor 12
- Symbol
- trip12 Nomenclature History
- Previous Names
-
- im:7149446
- si:ch211-272f3.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; negative regulation of nitrogen compound metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to localize to nucleoplasm. Is expressed in myotome. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12).
- Genome Resources
- Note
- None
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149446 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Clark-Baraitser syndrome | Alliance | Mental retardation, autosomal dominant 49 | 617752 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000569 | HECT domain |
Domain | IPR004170 | WWE domain |
Domain | IPR018123 | WWE domain, subgroup |
Homologous_superfamily | IPR011989 | Armadillo-like helical |
Homologous_superfamily | IPR016024 | Armadillo-type fold |
Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
Homologous_superfamily | IPR037197 | WWE domain superfamily |
Domain Details Per Protein
Protein | Length | Armadillo-like helical | Armadillo-type fold | HECT domain | HECT, E3 ligase catalytic domain | WWE domain | WWE domain, subgroup | WWE domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:F1RCR6
|
2026 | |||||||
UniProtKB:E9QHK4
|
32 | |||||||
UniProtKB:A0A2R8Q6F8
|
2111 | |||||||
UniProtKB:F1Q529
|
2053 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
trip12-202
(1)
|
258 nt | |
mRNA |
trip12-203
(1)
|
6552 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl