ZFIN Gene: trip12

ZFIN ID: ZDB-GENE-041111-262

ZFIN ID: ZDB-GENE-041111-262

Gene Name:

thyroid hormone receptor interactor 12

Gene Symbol:

trip12 Nomenclature History

Previous Names:

im:7149446, si:ch211-272f3.4 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 18 Mapping Details/Browsers

Description:

Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to DNA damage stimulus; negative regulation of nitrogen compound metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to localize to nucleoplasm. Is expressed in myotome. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 49. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12).

Genome Resources:

Alliance (1), Gene:564866 (1), Ensembl(GRCz11):ENSDARG00000061397 (1)

GENE EXPRESSION
Directly Submitted Expression Data:	6 figures (2 images) from Thisse et al., 2004 [IMAGE:7149446]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
	myotome whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa954	Point Mutation	Unknown	Premature Stop	ENU
sa8943	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa9786	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa9891	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa10603	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13854	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17600	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23366	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa29080	Point Mutation	Unknown	Splice Site	ENU

PHENOTYPE No data available

DISEASE ASSOCIATED WITH trip12 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Clark-Baraitser syndrome	Alliance	Mental retardation, autosomal dominant 49	617752

DISEASE ASSOCIATED WITH trip12 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cellular response to DNA damage stimulus (more)
Cellular Component	nucleoplasm (more)
Molecular Function	ubiquitin protein ligase activity (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	trip12-202 (1)	258	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	trip12-203 (1)	6552	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM trip12 No data available

MARKER RELATIONSHIPS

trip12 Contained in:	[BAC] CH73-160P19 (1), CH211-232P17 (1), CH211-272F3 (1)
trip12 Encodes:	[EST] IMAGE:7149446 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001347668 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX255879	173755 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8Q6F8 (1)	2111 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 28)

ORTHOLOGY for trip12 ( Chr: 18 )

CITATIONS (22)

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