ZFIN ID: ZDB-GENE-041111-259
Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Gene Symbol: ezh2    Nomenclature History

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Previous Names: eya2, im:7149338, zgc:136376, zgc:152758

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have promoter-specific chromatin binding activity. Involved in several processes, including fin regeneration; histone H3-K27 methylation; and tissue homeostasis. Predicted to localize to ESC/E(Z) complex. Is expressed in several structures, including central nervous system; digestive system; eye; gonad; and pectoral fin. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
Genome Resources: Alliance (1),  Gene:768133 (1),  Ensembl(GRCz11):ENSDARG00000010571 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5670 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1199 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1900 Point Mutation Unknown Splice Site ENU
    ul2 Indel Exon 2 Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ezh2
    2
    MO1-ezh2 N/A 2
    MO2-ezh2 N/A 1
    TALEN1-ezh2 1
    DISEASE ASSOCIATED WITH ezh2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Weaver syndrome Alliance Weaver syndrome 277590
    DISEASE ASSOCIATED WITH ezh2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive tract development (more)
    Cellular Component ESC/E(Z) complex (more)
    Molecular Function promoter-specific chromatin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ezh2-201 (1)    Ensembl 3760
    ezh2-202 (1)    Ensembl 1255
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ezh2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:ezh2,myl7:egfp) hsp70lmyl7 EGFPezh2 Danio rerio 1 1
    tg(hsp70l:ezh2_f681i_h703a,myl7:egfp) hsp70lmyl7 EGFPezh2 Danio rerio 1 1
    MARKER RELATIONSHIPS
    ezh2 Contained in: [BAC] DKEY-117J14 (1) (order this)
    ezh2 Encodes: [EST] IMAGE:7149338 (1)
    [cDNA] MGC:136376 (1), MGC:152758 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077279 (1) 3759 nt
    Genomic GenBank:BX005392 (1) 178765 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y9P9 (1) 770 aa
    Sequence Information (all 22)
    ORTHOLOGY for ezh2 ( Chr: 24 )
    CITATIONS (51)