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ZIRC
ZFIN ID: ZDB-GENE-041111-216
Gene Name: nebulin
Gene Symbol: neb    Nomenclature History

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Previous Names: im:6904860, im:7001777, im:7144538, im:7150492, si:ch211-168m7.5, wu:fc33b04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in muscle fiber development. Predicted to localize to the Z disc. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in nemaline myopathy 2. Is expressed in adaxial cell; heart; musculature system; pectoral fin; and somite. Orthologous to human NEB (nebulin).
Genome Resources: Alliance (1),  Gene:566928 (1),  Ensembl(GRCz11):ENSDARG00000032630 (1)
GENE EXPRESSION
All Expression Data: 28 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7144538]
  7 figures (38 images) from Thisse et al., 2004 [IMAGE:6904860]
  6 figures (10 images) from Thisse et al., 2004 [IMAGE:7150492]
  6 figures (12 images) from Thisse et al., 2004 [IMAGE:7152889]
  6 figures (5 images) from Thisse et al., 2004 [IMAGE:7162426]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2849 Point Mutation Donor Splice Site Splice Site ENU
sa154 Point Mutation Unknown Premature Stop ENU
sa906 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1610 Point Mutation Unknown Splice Site ENU
    sa10635 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11545 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11973 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15371 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15997 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16506 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18354 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21475 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21476 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30646 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34626 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34627 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34628 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34629 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34630 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38738 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41408 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-neb N/A 1
    MO2-neb N/A 1
    DISEASE ASSOCIATED WITH neb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nemaline myopathy 2 Alliance Nemaline myopathy 2, autosomal recessive 256030
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle fiber development (more)
    Cellular Component Z disc (more)
    Molecular Function actin binding (more)
    GO Terms (all 5)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA neb-206 (1)    Ensembl 523
    neb-207 (1)    Ensembl 2133
    neb-208 (1)    Ensembl 19401
    neb-209 (1)    Ensembl 1163
    ncRNA neb-003 (1)    Ensembl 459
    neb-004 (1)    Ensembl 639
    neb-005 (1)    Ensembl 763
    neb-008 (1)    Ensembl 826
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM neb No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009304675 (1)
    Genomic GenBank:CR391905 (1) 221511 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q1MSY0 (1) 6236 aa
    Sequence Clusters UniGene:156815 (1)
    Sequence Information (all 172)
    ORTHOLOGY for neb ( Chr: 9 )
    CITATIONS (28)