ZFIN ID: ZDB-GENE-041111-204
Gene Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b
Gene Symbol: hadhab    Nomenclature History

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Previous Names: im:7144234, zgc:158138 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha).
Genome Resources: Alliance (1),  Gene:793834 (1),  Ensembl(GRCz11):ENSDARG00000060594 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7144234]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11167 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17706 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hadhab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mitochondrial trifunctional protein deficiency Alliance Trifunctional protein deficiency 609015
    Fatty liver, acute, of pregnancy 609016
    HELLP syndrome, maternal, of pregnancy 609016
    LCHAD deficiency 609016
    DISEASE ASSOCIATED WITH hadhab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid beta-oxidation (more)
    Cellular Component mitochondrial fatty acid beta-oxidation multienzyme complex (more)
    Molecular Function 3-hydroxyacyl-CoA dehydrogenase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hadhab-201 (1)    Ensembl 2851
    ncRNA hadhab-002 (1)    Ensembl 941
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hadhab No data available
    MARKER RELATIONSHIPS
    hadhab Contained in: [BAC] DKEY-119A7 (1) (order this)
    hadhab Encodes: [EST] IMAGE:7144234 (1)
    [cDNA] MGC:158138 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089437 (1) 2870 nt
    Genomic GenBank:CT027616 (1) 200563 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A3KMH5 (1) 763 aa
    Sequence Information (all 24)
    ORTHOLOGY for hadhab ( Chr: 17 )
    CITATIONS (23)