ZFIN ID: ZDB-GENE-041111-150
Gene Name: myosin light chain kinase b
Gene Symbol: mylkb    Nomenclature History

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Previous Names: im:7142009, mlck1b (1), si:dkey-226n16.2, unm_sa1486

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase).
Genome Resources: Alliance (1),  Gene:492576 (1),  Ensembl(GRCz11):ENSDARG00000004753 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1486 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20668 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20669 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mylkb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 7 613780
    Megacystis-microcolon-intestinal hypoperistalsis syndrome 249210
    DISEASE ASSOCIATED WITH mylkb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component synapse (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mylkb-201 (1)    Ensembl 3482
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mylkb No data available
    MARKER RELATIONSHIPS
    mylkb Contained in: [BAC] DKEY-226N16 (1) (order this)
    mylkb Encodes: [EST] IMAGE:7142009 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009302263 (1)
    Genomic GenBank:CR853290 (1) 196624 nt
    Select Tool
    Polypeptide UniProtKB:E7FDK2 (1) 966 aa
    Sequence Information (all 9)
    ORTHOLOGY for mylkb ( Chr: 6 )
    CITATIONS (18)