ZFIN ID: ZDB-GENE-041105-7
Gene Name: asporin (LRR class 1)
Gene Symbol: aspn    Nomenclature History

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Previous Names: aspnl, bgl3, wu:fk08c11, zgc:109936

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and collagen binding activity. Predicted to localize to extracellular space. Is expressed in axial vasculature; chondrocranium; and pharyngeal arch. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin).
Genome Resources: Alliance (1),  Gene:65228 (1),  Ensembl(GRCz11):ENSDARG00000002192 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (8 images) from Thisse et al., 2004 [MGC:109936]
  7 figures (4 images) from Thisse et al., 2005 [eu237]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37439 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aspn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Lumbar disc degeneration} 603932
    {Osteoarthritis susceptibility 3} 607850
    DISEASE ASSOCIATED WITH aspn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aspn-201 (1)    Ensembl 1938
    aspn-202 (1)    Ensembl 1253
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aspn No data available
    MARKER RELATIONSHIPS
    aspn Contained in: [BAC] DKEY-42I9 (1) (order this)
    aspn Encodes: [EST] eu237 (1), fk08c11 (1)
    [cDNA] MGC:109936 (1), MGC:191639 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131713 (1) 1983 nt
    Genomic GenBank:BX465868 (1) 222195 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A8BBD1 (1) 370 aa
    Sequence Information (all 31)
    ORTHOLOGY for aspn ( Chr: 22 )
    CITATIONS (30)