Gene

myo5aa

ID
ZDB-GENE-041027-2
Name
myosin VAa
Symbol
myo5aa Nomenclature History
Previous Names
  • myo5a
  • si:dkey-266j9.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to localize to actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo5aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Griscelli syndrome type 1 Alliance Griscelli syndrome, type 1 214450
Associated With myo5aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002710 Dilute domain
Domain IPR004009 Myosin, N-terminal, SH3-like
Domain IPR036103 Class V myosin, motor domain
Domain IPR037988 Myosin 5a, cargo-binding domain
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class V myosin, motor domain Dilute domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin 5a, cargo-binding domain Myosin head, motor domain Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QYX4 1844
UniProtKB:F8W2H6 281
UniProtKB:F8W4K6 1890
UniProtKB:A0A0R4IXQ5 1824
UniProtKB:A0A2R8QSJ9 1887
UniProtKB:B3DJR2 1891
UniProtKB:Q1LXI2 1844
UniProtKB:A0A0R4IW90 1841
UniProtKB:A0A2R8RZK3 1887
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations