ZFIN Gene: myo5aa

ZFIN ID: ZDB-GENE-041027-2

ZFIN ID: ZDB-GENE-041027-2

Gene Name:

myosin VAa

Gene Symbol:

myo5aa Nomenclature History

Previous Names:

myo5a, si:dkey-266j9.1

Gene Type:

protein_coding_gene

Location:

Chr: 18 Mapping Details/Browsers

Description:

Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to localize to actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).

Genome Resources:

Alliance (1), Gene:562188 (1), Ensembl(GRCz11):ENSDARG00000061635 (1)

GENE EXPRESSION
All Expression Data:	4 figures from 2 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 4 (96.0h-120.0h)
	anterior lateral line placode forebrain intestine midbrain neural tube neuron neural crest derived nucleus of the medial longitudinal fasciculus medulla oblongata nucleus of the tract of the anterior commissure nucleus of the tract of the postoptic commissure rhombomere spinal cord trigeminal placode

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la020430Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa23354	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23355	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36702	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH myo5aa HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Griscelli syndrome type 1	Alliance	Griscelli syndrome, type 1	214450

DISEASE ASSOCIATED WITH myo5aa VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	actin filament organization (more)
Cellular Component	myosin complex (more)
Molecular Function	actin binding (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	myo5aa-202 (1)	5535	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	myo5aa-203 (1)	844	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	myo5aa-204 (1)	5735	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myo5aa-005 (1)	815	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM myo5aa No data available

MARKER RELATIONSHIPS

myo5aa Contained in:	[BAC] CH211-143E19 (1), DKEY-266J9 (1) (order this)
myo5aa Encodes:	[cDNA] MGC:195213 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005173675 (1)	5901 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_018395043 (1)		Blast at MegaBLAST
Polypeptide	UniProtKB:B3DJR2 (1)	1891 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 65)

ORTHOLOGY for myo5aa ( Chr: 18 )

CITATIONS (32)

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