Gene

myo5aa

ID

ZDB-GENE-041027-2

Name

myosin VAa

Symbol

myo5aa Nomenclature History

Previous Names

myo5a
si:dkey-266j9.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to localize to actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).

Genome Resources

Note

None

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo5aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Griscelli syndrome type 1	Alliance	Griscelli syndrome, type 1	214450

Associated With myo5aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR001609	Myosin head, motor domain
Domain	IPR002710	Dilute domain
Domain	IPR004009	Myosin, N-terminal, SH3-like
Domain	IPR036103	Class V myosin, motor domain
Domain	IPR037988	Myosin 5a, cargo-binding domain
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class V myosin, motor domain	Dilute domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin 5a, cargo-binding domain	Myosin head, motor domain	Myosin, N-terminal, SH3-like	Myosin S1 fragment, N-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QYX4 InterPro	1844
UniProtKB:F8W2H6 InterPro	281
UniProtKB:F8W4K6 InterPro	1890
UniProtKB:A0A0R4IXQ5 InterPro	1824
UniProtKB:A0A2R8QSJ9 InterPro	1887
UniProtKB:B3DJR2 InterPro	1891
UniProtKB:Q1LXI2 InterPro	1844
UniProtKB:A0A0R4IW90 InterPro	1841
UniProtKB:A0A2R8RZK3 InterPro	1887

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	myo5aa-202 (1) Ensembl	5535 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myo5aa-203 (1) Ensembl	844 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myo5aa-204 (1) Ensembl	5735 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myo5aa-005 (1) Ensembl	815 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations