ZFIN ID: ZDB-GENE-041027-2
Gene Name: myosin VAa
Gene Symbol: myo5aa    Nomenclature History

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Previous Names: myo5a, si:dkey-266j9.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Orthologous to human MYO5A (myosin VA).
Genome Resources: Alliance (1),  Gene:562188 (1),  Ensembl(GRCz11):ENSDARG00000061635 (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH myo5aa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Griscelli syndrome type 1 Alliance Griscelli syndrome, type 1 214450
DISEASE ASSOCIATED WITH myo5aa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myosin complex (more)
Molecular Function actin binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002710 Dilute domain
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain IPR036103 Class V myosin, motor domain
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain IPR037988 Myosin 5a, cargo-binding domain
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA myo5aa-202 (1)    Ensembl 5535
myo5aa-203 (1)    Ensembl 844
myo5aa-204 (1)    Ensembl 5735
ncRNA myo5aa-005 (1) 815
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM myo5aa No data available
MARKER RELATIONSHIPS
myo5aa Contained in: [BAC] CH211-143E19 (1), DKEY-266J9 (1) (order this)
myo5aa Encodes: [cDNA] MGC:195213 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_005173675 (1) 5901 bp
Genomic RefSeq:NW_018395043 (1) Blast at MegaBLAST
Polypeptide UniProtKB:B3DJR2 (1) 1891 aa
Sequence Information (all 65)
ORTHOLOGY for myo5aa ( Chr: 18 )
CITATIONS (31)