| ZFIN ID: ZDB-GENE-041027-2 |
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| Gene Name: | myosin VAa | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | myo5aa Nomenclature History |
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Attributions
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| Previous Names: | myo5a, si:dkey-266j9.1 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 18 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Orthologous to human MYO5A (myosin VA). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:562188 (1), Ensembl(GRCz11):ENSDARG00000061635 (1) | |||||||||||||
| All Expression Data: | 4 figures from 2 publications |
| Wild-type Stages, Structures: | Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 4 (96.0h-120.0h) |
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MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| la020430Tg | Transgenic Insertion | Unknown | Unknown | DNA |
|
| sa23354 | Point Mutation | Unknown | Splice Site | ENU |
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| sa23355 | Point Mutation | Unknown | Splice Site | ENU |
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| sa36702 | Point Mutation | Unknown | Premature Stop | ENU |
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| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 1 | Alliance | Griscelli syndrome, type 1 | 214450 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Cellular Component | myosin complex (more) |
| Molecular Function | actin binding (more) |
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR002710 | Dilute domain |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Domain | IPR036103 | Class V myosin, motor domain |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
| Domain | IPR037988 | Myosin 5a, cargo-binding domain |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
myo5aa-202
(1)
|
5535 |
Select Tool
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|
myo5aa-203
(1)
|
844 |
Select Tool
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myo5aa-204
(1)
|
5735 |
Select Tool
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| ncRNA | myo5aa-005 (1) | 815 |
Select Tool
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| Browsers: NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM myo5aa
No data available
MARKER RELATIONSHIPS
| myo5aa Contained in: | [BAC] CH211-143E19 (1), DKEY-266J9 (1) (order this) |
| myo5aa Encodes: | [cDNA] MGC:195213 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_005173675 (1) | 5901 bp |
Select Tool
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| Genomic | RefSeq:NW_018395043 (1) | Blast at MegaBLAST | |
| Polypeptide | UniProtKB:B3DJR2 (1) | 1891 aa |
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ORTHOLOGY for myo5aa (
Chr:
18
)
CITATIONS (31)