Gene
myo5aa
- ID
- ZDB-GENE-041027-2
- Name
- myosin VAa
- Symbol
- myo5aa Nomenclature History
- Previous Names
-
- myo5a
- si:dkey-266j9.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to localize to actin cytoskeleton; cytoplasm; and vesicle. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).
- Genome Resources
- Note
- None
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Griscelli syndrome type 1 | Alliance | Griscelli syndrome, type 1 | 214450 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR000048 | IQ motif, EF-hand binding site |
Domain | IPR001609 | Myosin head, motor domain |
Domain | IPR002710 | Dilute domain |
Domain | IPR004009 | Myosin, N-terminal, SH3-like |
Domain | IPR036103 | Class V myosin, motor domain |
Domain | IPR037988 | Myosin 5a, cargo-binding domain |
Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
Protein | Length | Class V myosin, motor domain | Dilute domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin 5a, cargo-binding domain | Myosin head, motor domain | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QYX4
|
1844 | |||||||||
UniProtKB:F8W2H6
|
281 | |||||||||
UniProtKB:F8W4K6
|
1890 | |||||||||
UniProtKB:A0A0R4IXQ5
|
1824 | |||||||||
UniProtKB:A0A2R8QSJ9
|
1887 | |||||||||
UniProtKB:B3DJR2
|
1891 | |||||||||
UniProtKB:Q1LXI2
|
1844 | |||||||||
UniProtKB:A0A0R4IW90
|
1841 | |||||||||
UniProtKB:A0A2R8RZK3
|
1887 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
myo5aa-202
(1)
|
5535 nt | |
mRNA |
myo5aa-203
(1)
|
844 nt | |
mRNA |
myo5aa-204
(1)
|
5735 nt | |
ncRNA |
myo5aa-005
(1)
|
815 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl