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Gene

flnb

ID
ZDB-GENE-041026-1
Name
filamin B, beta (actin binding protein 278)
Symbol
flnb Nomenclature History
Previous Names
  • si:ch211-222g5.4
  • si:ch211-222g5.6
  • si:ch211-222g5.7
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable actin binding activity. Predicted to act upstream of or within actin cytoskeleton organization and cell differentiation. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flnb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atelosteogenesis Alliance Atelosteogenesis, type I 108720
atelosteogenesis Alliance Atelosteogenesis, type III 108721
Boomerang dysplasia Alliance Boomerang dysplasia 112310
Larsen syndrome Alliance Larsen syndrome 150250
spondylocarpotarsal synostosis syndrome Alliance Spondylocarpotarsal synostosis syndrome 272460
Associated With flnb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001715 Calponin homology domain
Family IPR029874 Filamin-B
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036872 CH domain superfamily
Repeat IPR001298 Filamin/ABP280 repeat
Repeat IPR017868 Filamin/ABP280 repeat-like
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily Filamin/ABP280 repeat Filamin/ABP280 repeat-like Filamin-B Immunoglobulin E-set Immunoglobulin-like fold
UniProtKB:F1QGL5 2233
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations