Gene

tll1

ID
ZDB-GENE-041020-1
Name
tolloid-like 1
Symbol
tll1 Nomenclature History
Previous Names
  • tld (1)
  • mfn
  • mini fin
  • tolloid (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits metallopeptidase activity. Involved in several processes, including determination of ventral identity; embryonic morphogenesis; and post-anal tail morphogenesis. Is expressed in margin; neural plate; tail bud; vascular cord; and vasculature. Human ortholog(s) of this gene implicated in atrial heart septal defect 6. Orthologous to human TLL1 (tolloid like 1).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tll1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 6 Alliance Atrial septal defect 6 613087
Associated With tll1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001506 Peptidase M12A
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR034036 Tolloid/BMP1 peptidase domain
Family IPR015446 Bone morphogenetic protein 1/tolloid-like protein
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Bone morphogenetic protein 1/tolloid-like protein CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Metallopeptidase, catalytic domain superfamily Peptidase M12A Peptidase, metallopeptidase Spermadhesin, CUB domain superfamily Tolloid/BMP1 peptidase domain
UniProtKB:B3DJN6 1022
UniProtKB:O57460 1022
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations