ZFIN ID: ZDB-GENE-041020-1
Gene Name: tolloid-like 1
Gene Symbol: tll1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: tld (1), mfn, mini fin, tolloid (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits metallopeptidase activity. Involved in several processes, including determination of ventral identity; embryonic morphogenesis; and post-anal tail morphogenesis. Human ortholog(s) of this gene implicated in atrial heart septal defect 6. Is expressed in margin; neural plate; tail bud; vascular cord; and vasculature. Orthologous to human TLL1 (tolloid like 1).
Genome Resources: Alliance (1),  Gene:474335 (1),  Ensembl(GRCz11):ENSDARG00000037429 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021034Tg Transgenic Insertion Unknown Unknown DNA
sa387 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19476 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb241c Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc263a Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tf215a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tll1_unspecified Unspecified Unknown Unknown
    tm124 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm124a Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tn217b Point Mutation Unknown Missense ENU
    tt203a Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tv9b Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ty130a Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko395a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko395b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tll1 1
    MO1-tll1 N/A 3
    MO2-tll1 N/A 2
    DISEASE ASSOCIATED WITH tll1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 6 Alliance Atrial septal defect 6 613087
    DISEASE ASSOCIATED WITH tll1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular region (more)
    Molecular Function metallopeptidase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR000859 CUB domain
    Domain IPR001506 Peptidase M12A
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR006026 Peptidase, metallopeptidase
    Conserved_site IPR013032 EGF-like, conserved site
    Family IPR015446 Bone morphogenetic protein 1/tolloid-like protein
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Domain IPR034036 Tolloid/BMP1 peptidase domain
    Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tll1-201 (1)    Ensembl 4633
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tll1 No data available
    MARKER RELATIONSHIPS
    tll1 Contained in: [BAC] CH211-198G9 (1), DKEY-285B22 (1) (order this)
    tll1 Encodes: [cDNA] MGC:195104 (1), MGC:195127 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131010 (1) 4633 bp
    Genomic GenBank:BX119983 (1) 172227 bp
    Select Tool
    Polypeptide UniProtKB:B3DJN6 (1) 1022 aa
    Sequence Information (all 18)
    ORTHOLOGY for tll1 ( Chr: 1 )
    CITATIONS (57)