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Gene

tll1

ID
ZDB-GENE-041020-1
Name
tolloid-like 1
Symbol
tll1 Nomenclature History
Previous Names
  • tld (1)
  • mfn
  • mini fin
  • tolloid (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables metallopeptidase activity. Acts upstream of or within several processes, including determination of ventral identity; embryonic morphogenesis; and post-anal tail morphogenesis. Is expressed in margin; neural plate; tail bud; vascular cord; and vasculature. Human ortholog(s) of this gene implicated in atrial heart septal defect 6. Orthologous to human TLL1 (tolloid like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tll1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 6 Alliance Atrial septal defect 6 613087
Associated With tll1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001506 Peptidase M12A
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR034036 Tolloid/BMP1 peptidase domain
Family IPR015446 Bone morphogenetic protein 1/tolloid-like protein
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Bone morphogenetic protein 1/tolloid-like protein CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Metallopeptidase, catalytic domain superfamily Peptidase M12A Peptidase, metallopeptidase Spermadhesin, CUB domain superfamily Tolloid/BMP1 peptidase domain
UniProtKB:B3DJN6 1022
UniProtKB:O57460 1022
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations