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Gene

adgrg6

ID
ZDB-GENE-041014-357
Name
adhesion G protein-coupled receptor G6
Symbol
adgrg6 Nomenclature History
Previous Names
  • bge
  • big ears (1)
  • gpr126
  • lau
  • lauscher (1)
  • si:ch211-202p1.3 (1)
  • unm st49
  • unm_st49
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Enables G protein-coupled receptor activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including animal organ development; cAMP-mediated signaling; and myelination. Acts upstream of or within several processes, including animal organ morphogenesis; myelination; and regulation of sprouting angiogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including head; otic vesicle; pericardial region; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
49 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adgrg6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lethal congenital contracture syndrome 9 616503
Associated With adgrg6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017983 GPCR, family 2, secretin-like, conserved site
Domain IPR000203 GPS motif
Domain IPR000859 CUB domain
Domain IPR017981 GPCR, family 2-like
Family IPR000832 GPCR, family 2, secretin-like
Family IPR001759 Pentraxin-related
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily CUB domain GPCR, family 2-like GPCR, family 2, secretin-like GPCR, family 2, secretin-like, conserved site GPS motif Pentraxin-related Spermadhesin, CUB domain superfamily
UniProtKB:C6KFA3 1185
UniProtKB:F1Q7U5 1240
UniProtKB:U3JAN0 106
UniProtKB:E7F1G3 1184
UniProtKB:U3JAV0 88
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations