Gene

adgrg6

ID
ZDB-GENE-041014-357
Name
adhesion G protein-coupled receptor G6
Symbol
adgrg6 Nomenclature History
Previous Names
  • bge
  • big ears (1)
  • gpr126
  • lau
  • lauscher (1)
  • si:ch211-202p1.3 (1)
  • unm st49
  • unm_st49
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits G protein-coupled receptor activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including animal organ morphogenesis; cAMP-mediated signaling; and myelination. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including head; otic vesicle; pericardial region; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
43 figures from 15 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adgrg6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lethal congenital contracture syndrome 9 616503
Associated With adgrg6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017983 GPCR, family 2, secretin-like, conserved site
Domain IPR000203 GPS motif
Domain IPR000859 CUB domain
Domain IPR017981 GPCR, family 2-like
Family IPR000832 GPCR, family 2, secretin-like
Family IPR001759 Pentraxin-related
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily CUB domain GPCR, family 2-like GPCR, family 2, secretin-like GPCR, family 2, secretin-like, conserved site GPS motif Pentraxin-related Spermadhesin, CUB domain superfamily
UniProtKB:F1Q7U5 1240
UniProtKB:U3JAN0 106
UniProtKB:E7F1G3 1184
UniProtKB:U3JAV0 88
UniProtKB:C6KFA3 1185
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations