ZFIN ID: ZDB-GENE-041014-322
Gene Name: hemicentin 1
Gene Symbol: hmcn1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: nag, nagel (1), nel (1), si:ch211-169j21.3

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in basement membrane organization and fin morphogenesis. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Is expressed in several structures, including axis; epidermis; median fin fold; notochord; and pectoral fin. Orthologous to human HMCN1 (hemicentin 1).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000016936 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr22 Point Mutation Exon 55 Premature Stop ENU
mn0263Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9806 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11019 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16438 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17994 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19239 Point Mutation Unknown Splice Site ENU
    sa23756 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23757 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30717 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32306 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32307 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37092 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37093 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37094 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37095 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39291 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43488 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43489 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ta84 Unknown Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • tb22 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc8 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te335 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg254b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj258a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl28b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl246a Unknown Unknown Unknown ENU
    tm42b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm51 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm68 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm147c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tn3 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tn210 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp41a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq207 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq274 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr3 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tt231 Unknown Unknown Unknown ENU
    tu27a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw234b Unknown Unknown Unknown ENU
    ty58 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty124b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hmcn1
    1
    MO1-hmcn1 N/A 1
    MO2-hmcn1 N/A 1
    DISEASE ASSOCIATED WITH hmcn1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 1 Alliance {Macular degeneration, age-related, 1} 603075
    DISEASE ASSOCIATED WITH hmcn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process basement membrane organization (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR006605 G2 nidogen/fibulin G2F
    Domain IPR007110 Immunoglobulin-like domain
    Homologous_superfamily IPR009017 Green fluorescent protein
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Domain IPR013098 Immunoglobulin I-set
    Domain IPR013106 Immunoglobulin V-set domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR026823 Complement Clr-like EGF domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hmcn1-202 (1)    Ensembl 18491
    hmcn1-203 (1)    Ensembl 560
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hmcn1 No data available
    MARKER RELATIONSHIPS
    hmcn1 Contained in: [BAC] CH211-169J21 (1), DKEYP-11G8 (1)
    hmcn1 Encodes: [EST] eu1648 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:BX248238 (1) 158302 bp
    Select Tool
    Polypeptide UniProtKB:F1QVQ2 (1) 5616 aa
    Sequence Information (all 8)
    ORTHOLOGY for hmcn1 ( Chr: 20 )
    CITATIONS (29)