ZFIN is now using GRCz12tu for Genomic Data
Gene
hmcn1
- ID
- ZDB-GENE-041014-322
- Name
- hemicentin 1
- Symbol
- hmcn1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within basement membrane organization and fin morphogenesis. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including axis; epidermis; median fin fold; notochord; and tail bud. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Orthologous to human HMCN1 (hemicentin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1648 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {Macular degeneration, age-related, 1} | 603075 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR006605 | G2 nidogen/fibulin G2F |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Domain | IPR056475 | Hemicentin/VWA7, galactose-binding domain-like |
| Family | IPR050958 | Cell Adhesion and Cytoskeletal Organization |
| Homologous_superfamily | IPR009017 | Green fluorescent protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Adhesion and Cytoskeletal Organization | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | G2 nidogen/fibulin G2F | Green fluorescent protein | Growth factor receptor cysteine-rich domain superfamily | Hemicentin/VWA7, galactose-binding domain-like | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | NOTCH1 EGF-like calcium-binding domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AKX8 | InterPro | 5502 | |||||||||||||||||||||
| UniProtKB:A0A8M3B479 | InterPro | 3868 | |||||||||||||||||||||
| UniProtKB:A0A8M2B7L6 | InterPro | 5623 | |||||||||||||||||||||
| UniProtKB:D7PS96 | InterPro | 5615 | |||||||||||||||||||||
| UniProtKB:A0AB32T9J5 | InterPro | 5616 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers