ZFIN ID: ZDB-GENE-041014-300
Gene Name: insulin-like growth factor 2 receptor
Gene Symbol: igf2r    Nomenclature History

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Previous Names: CI-MPR (1), si:ch211-214g8.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have insulin-like growth factor binding activity and mannose binding activity. Predicted to be involved in lysosomal transport. Predicted to localize to the late endosome; plasma membrane; and trans-Golgi network. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Is expressed in nervous system; presumptive neural retina; and somite. Orthologous to human IGF2R (insulin like growth factor 2 receptor).
Genome Resources: Alliance (1),  Gene:557061 (1),  Ensembl(GRCz11):ENSDARG00000006094 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH igf2r HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
DISEASE ASSOCIATED WITH igf2r VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process lysosomal transport (more)
Cellular Component integral component of membrane (more)
Molecular Function insulin-like growth factor binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Repeat IPR000479 Cation-independent mannose-6-phosphate receptor repeat
Domain IPR000562 Fibronectin type II domain
Homologous_superfamily IPR009011 Mannose-6-phosphate receptor binding domain superfamily
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA igf2r-201 (1)    Ensembl 7891
igf2r-202 (1)    Ensembl 612
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM igf2r No data available
MARKER RELATIONSHIPS
igf2r Contained in: [BAC] CH211-214G8 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001039627 (1) 7380 bp
Genomic GenBank:AL929119 (1) 136176 bp
Select Tool
Polypeptide UniProtKB:Q2TTK0 (1) 2459 aa
Sequence Information (all 24)
ORTHOLOGY for igf2r ( Chr: 20 )
CITATIONS (31)