igf2r

ID

ZDB-GENE-041014-300

Name

insulin-like growth factor 2 receptor

Symbol

igf2r Nomenclature History

Previous Names

CI-MPR (1)
si:ch211-214g8.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable insulin-like growth factor binding activity. Predicted to be involved in lysosomal transport. Predicted to be located in membrane. Predicted to be active in late endosome; plasma membrane; and trans-Golgi network. Is expressed in nervous system; presumptive neural retina; and somite. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igf2r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, somatic	114550

Associated With igf2r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000562	Fibronectin type II domain
Domain	IPR044865	MRH domain
Homologous_superfamily	IPR009011	Mannose-6-phosphate receptor binding domain superfamily
Homologous_superfamily	IPR013806	Kringle-like fold
Homologous_superfamily	IPR036943	Fibronectin type II domain superfamily
Repeat	IPR000479	Cation-independent mannose-6-phosphate receptor repeat