Gene

bub1ba

ID

ZDB-GENE-041014-120

Name

BUB1 mitotic checkpoint serine/threonine kinase Ba

Symbol

bub1ba Nomenclature History

Previous Names

fi15g07
si:ch211-158b22.2
wu:fi15g07

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint. Predicted to localize to condensed nuclear chromosome kinetochore. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bub1ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
mosaic variegated aneuploidy syndrome 1	Alliance	Mosaic variegated aneuploidy syndrome 1	257300
		[Premature chromatid separation trait]	176430

Associated With bub1ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR015661	Mitotic spindle checkpoint protein Bub1/Mad3

Domain Details Per Protein

Protein	Length	Mitotic spindle checkpoint protein Bub1/Mad3
UniProtKB:A0A8M6Z3I8 InterPro	645
UniProtKB:A0A8M9PQ72 InterPro	720
UniProtKB:A0A8M2B836 InterPro	721
UniProtKB:A0A8M9PTL0 InterPro	720
UniProtKB:A0A8M9P355 InterPro	684
UniProtKB:A0A8M6YWU6 InterPro	646
UniProtKB:A0A8M2B7V1 InterPro	721
UniProtKB:F1Q636 InterPro	722
UniProtKB:F1RA38 InterPro	721

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	bub1ba-202 (1) Ensembl	Havana	2394 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	bub1ba-204 (1) Ensembl	Havana	404 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	bub1ba-003 (1) Ensembl	Havana	861 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations