ZFIN ID: ZDB-GENE-041014-1
Gene Name: MET proto-oncogene, receptor tyrosine kinase
Gene Symbol: met    Nomenclature History

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Previous Names: c-met (1), cmet (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have Wnt-protein binding activity and hepatocyte growth factor-activated receptor activity. Involved in generation of neurons; gland development; and pectoral fin development. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase).
Genome Resources: Alliance (1),  Gene:100150664 (1),  Ensembl(GRCz11):ENSDARG00000070903 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028683Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pc36 Indel Unknown Unknown ZINC_FINGER_NUCLEASE
    sa16304 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18672 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24650 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44271 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • umu7 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-met 1
    MO1-met N/A 6
    MO2-met N/A 6
    MO3-met N/A 1
    MO4-met N/A 1
    MO5-met N/A 1
    MO6-met N/A 1
    DISEASE ASSOCIATED WITH met HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 97 Alliance ?Deafness, autosomal recessive 97 616705
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, childhood type, somatic 114550
    papillary renal cell carcinoma Alliance Renal cell carcinoma, papillary, 1, familial and somatic 605074
    {Osteofibrous dysplasia, susceptibility to} 607278
    DISEASE ASSOCIATED WITH met VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 33)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR001627 Sema domain
    Repeat IPR002165 Plexin repeat
    Domain IPR002909 IPT domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR014756 Immunoglobulin E-set
    Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Domain IPR016201 PSI domain
    Family IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Family IPR031148 Plexin family
    Homologous_superfamily IPR036352 Sema domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA met-201 (1)    Ensembl 4382
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM met
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(met:GAL4,UAS:EGFP) met EGFPGAL4 Danio rerio 1 9
    Tg(met:mCherry-2A-KALTA4) met 2AKALTA4mCherry Danio rerio 1 2
    MARKER RELATIONSHIPS
    met Contained in: [BAC] CH211-226K23 (1)
    met Encodes: [EST] IMAGE:7153684 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007124 (1) 4157 bp
    Genomic GenBank:DP000237 (1) 468356 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QLR7 (1) 1382 aa
    Sequence Information (all 26)
    ORTHOLOGY for met ( Chr: 25 )
    CITATIONS (57)