Gene

ercc8

ID
ZDB-GENE-041010-60
Name
excision repair cross-complementation group 8
Symbol
ercc8 Nomenclature History
Previous Names
  • CSA (1)
  • zgc:103550
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Is predicted to contribute to ubiquitin-protein transferase activity. Involved in response to UV. Predicted to localize to Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ercc8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cockayne syndrome Alliance Cockayne syndrome, type A 216400
UV-sensitive syndrome Alliance UV-sensitive syndrome 2 614621
Associated With ercc8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR017986 WD40-repeat-containing domain
Family IPR042238 DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1 G-protein beta WD-40 repeat WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A9C3R4 178
UniProtKB:A9C3R3 400
UniProtKB:A8KBN5 400
UniProtKB:A0A2R8Q1A4 372
UniProtKB:Q5XJ81 400
UniProtKB:A8KC61 400
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations