ZFIN ID: ZDB-GENE-041010-57
Gene Name: CLN6 transmembrane ER protein a
Gene Symbol: cln6a    Nomenclature History

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Previous Names: cln6, zgc:103565

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to be involved in lysosome organization. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis; neuronal ceroid lipofuscinosis 4A; and neuronal ceroid lipofuscinosis 6. Orthologous to human CLN6 (CLN6 transmembrane ER protein).
Genome Resources: Alliance (1),  Gene:449809 (1),  Ensembl(GRCz11):ENSDARG00000077584 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103565]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016089Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa904 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10876 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cln6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neuronal ceroid lipofuscinosis 4A Alliance Ceroid lipofuscinosis, neuronal, Kufs type, adult onset 204300
    neuronal ceroid lipofuscinosis 6 Alliance Ceroid lipofuscinosis, neuronal, 6 601780
    DISEASE ASSOCIATED WITH cln6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lysosome organization (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cln6a-201 (1)    Ensembl 1748
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cln6a No data available
    MARKER RELATIONSHIPS
    cln6a Encodes: [cDNA] MGC:103565 (1), MGC:191237 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001005982 (1) 1719 nt
    Polypeptide UniProtKB:A0A1D5NSU0 (1) 298 aa
    Sequence Information (all 15)
    ORTHOLOGY for cln6a ( Chr: 7 )
    CITATIONS (23)