ZFIN ID: ZDB-GENE-041010-54
Gene Name: fibulin 5
Gene Symbol: fbln5    Nomenclature History

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Previous Name: zgc:103575 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in elastic fiber assembly. Predicted to localize to extracellular space. Is expressed in bulbus arteriosus. Human ortholog(s) of this gene implicated in age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5).
Genome Resources: Alliance (1),  Gene:449806 (1),  Ensembl(GRCz11):ENSDARG00000039273 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103575]
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH fbln5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant cutis laxa 2 Alliance ?Cutis laxa, autosomal dominant 2 614434
autosomal recessive cutis laxa type IA Alliance Cutis laxa, autosomal recessive, type IA 219100
Macular degeneration, age-related, 3 608895
Neuropathy, hereditary, with or without age-related macular degeneration 608895
DISEASE ASSOCIATED WITH fbln5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process elastic fiber assembly (more)
Cellular Component extracellular space (more)
Molecular Function calcium ion binding (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fbln5-201 (1)    Ensembl 2428
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM fbln5 No data available
MARKER RELATIONSHIPS
fbln5 Contained in: [BAC] CH211-10A23 (1)
fbln5 Encodes: [cDNA] MGC:103575 (1), MGC:193076 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005979 (1) 2439 nt
Genomic GenBank:BX323843 (1) 128245 nt
Select Tool
Polypeptide UniProtKB:B8A4X3 (1) 477 aa
Sequence Information (all 15)
ORTHOLOGY for fbln5 ( Chr: 13 )
CITATIONS (21)