Gene

casp6b.1

ID

ZDB-GENE-041010-48

Name

caspase 6b.1, apoptosis-related cysteine peptidase

Symbol

casp6b.1 Nomenclature History

Previous Names

casp6b (1)
casp6l1
caspase-6b (1)
zgc:103604

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable cysteine-type endopeptidase activity involved in execution phase of apoptosis. Predicted to be involved in apoptotic process. Predicted to act upstream of or within proteolysis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:103604 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp6b.1 Human Ortholog

No data available

Associated With casp6b.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Family	IPR002398	Peptidase C14 family
Family	IPR037554	Caspase-6
Homologous_superfamily	IPR029030	Caspase-like domain superfamily

Domain Details Per Protein

Protein	Length	Caspase-6	Caspase-like domain superfamily	Peptidase C14A, caspase catalytic domain	Peptidase C14, caspase non-catalytic subunit p10	Peptidase C14 family	Peptidase C14, p20 domain	Peptidase family C14A, His active site
UniProtKB:E9QET6 InterPro	168
UniProtKB:A0A2U9DQN1 InterPro	261
UniProtKB:A0A2R8RHQ5 InterPro	242
UniProtKB:Q5XJ68 InterPro	242
UniProtKB:F1RB78 InterPro	249
UniProtKB:E9QBR7 InterPro	253

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	casp6l1-201 (1) Ensembl	1235 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	casp6l1-202 (1) Ensembl	783 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	casp6l1-203 (1) Ensembl	794 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations