Community Action Needed: Please respond to the NIH RFI
Gene

serpina7

ID
ZDB-GENE-041010-47
Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
Symbol
serpina7 Nomenclature History
Previous Names
  • wu:fb66f08
  • wu:fb68e04
  • zgc:103617
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including SERPINA1 (serpin family A member 1); SERPINA12 (serpin family A member 12); and SERPINA7 (serpin family A member 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With serpina7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Thyroxine-binding globulin QTL] 300932
Associated With serpina7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023795 Serpin, conserved site
Domain IPR023796 Serpin domain
Family IPR000215 Serpin family
Homologous_superfamily IPR036186 Serpin superfamily
Homologous_superfamily IPR042178 Serpin superfamily, domain 1
Homologous_superfamily IPR042185 Serpin superfamily, domain 2
Domain Details Per Protein
Protein Length Serpin, conserved site Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
UniProtKB:A8E5C1 372
UniProtKB:A8E5C2 372
UniProtKB:Q5XJ64 372
UniProtKB:F8W5C3 410
UniProtKB:A0A2R8PXE0 410
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations