Gene
ppp2r2bb
- ID
- ZDB-GENE-041010-39
- Name
- protein phosphatase 2, regulatory subunit B, beta b
- Symbol
- ppp2r2bb Nomenclature History
- Previous Names
-
- ppp2r2b
- zgc:101861
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to localize to cytosol and protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101861 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 12 | Alliance | Spinocerebellar ataxia 12 | 604326 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018067 | Protein phosphatase 2A regulatory subunit PR55, conserved site |
| Family | IPR000009 | Protein phosphatase 2A regulatory subunit PR55 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | Protein phosphatase 2A regulatory subunit PR55 | Protein phosphatase 2A regulatory subunit PR55, conserved site | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q610
|
446 | |||||
|
UniProtKB:A0A8M9PCQ6
|
433 | |||||
|
UniProtKB:A0A0R4IEA6
|
443 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp2r2bb-201
(1)
|
Ensembl | 491 nt | ||
| mRNA |
ppp2r2bb-202
(1)
|
Ensembl | 1,920 nt | ||
| mRNA |
ppp2r2bb-203
(1)
|
Ensembl | 1,694 nt | ||
| mRNA |
ppp2r2bb-204
(1)
|
Ensembl | 1,302 nt |
Interactions and Pathways
No data available
Plasmids
No data available