Gene

tars1

ID
ZDB-GENE-041010-218
Name
threonyl-tRNA synthetase 1
Symbol
tars1 Nomenclature History
Previous Names
  • tars
  • wu:fb07c05
  • wu:fb39c12
  • zgc:92586 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have threonine-tRNA ligase activity. Involved in branching involved in blood vessel morphogenesis and regulation of sprouting angiogenesis. Predicted to localize to cytoplasm. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; optic vesicle; and segmental plate. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nonphotosensitive trichothiodystrophy 7 Alliance Trichothiodystrophy 7, nonphotosensitive 618546
Associated With tars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR004095 TGS
Domain IPR004154 Anticodon-binding
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR012947 Threonyl/alanyl tRNA synthetase, SAD
Domain IPR033728 Threonine-tRNA ligase catalytic core domain
Family IPR002320 Threonine-tRNA ligase, class IIa
Homologous_superfamily IPR012675 Beta-grasp domain superfamily
Homologous_superfamily IPR012676 TGS-like
Homologous_superfamily IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
Homologous_superfamily IPR036621 Anticodon-binding domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Anticodon-binding Anticodon-binding domain superfamily Beta-grasp domain superfamily TGS TGS-like Threonine-tRNA ligase catalytic core domain Threonine-tRNA ligase, class IIa Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily Threonyl/alanyl tRNA synthetase, SAD
UniProtKB:Q5CZT2 359
UniProtKB:Q5XIZ3 624
UniProtKB:A2BIM7 718
UniProtKB:A0A2R8QSD2 680
UniProtKB:A8KC60 718
UniProtKB:A0A2R8QS44 605
UniProtKB:A0A2R8RVT1 588
UniProtKB:A0A2R8QF48 701
UniProtKB:A0A2R8QDW5 692
UniProtKB:A0A2R8QLE0 593
UniProtKB:A0A2R8QAT8 689
UniProtKB:A0A2R8PXY1 576
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations