ZFIN ID: ZDB-GENE-041010-208
Gene Name: glutathione synthetase
Gene Symbol: gss    Nomenclature History

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Previous Names: sb:cb814, zgc:101574

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in head kidney; lens; pronephric duct; and solid lens vesicle. Orthologous to human GSS (glutathione synthetase).
Genome Resources: Alliance (1),  Gene:450084 (1),  Ensembl(GRCz11):ENSDARG00000037706 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Directly Submitted Expression Data: 3 figures (7 images) from Thisse et al., 2001 [cb814]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gss HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glutathione synthetase deficiency 266130
Hemolytic anemia due to glutathione synthetase deficiency 231900
DISEASE ASSOCIATED WITH gss VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glutathione biosynthetic process (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR004887 Glutathione synthase, substrate-binding domain
Family IPR005615 Glutathione synthase
Homologous_superfamily IPR014042 Glutathione synthase, alpha-helical
Homologous_superfamily IPR014049 Glutathione synthase, N-terminal, eukaryotic
Homologous_superfamily IPR014709 Glutathione synthase, C-terminal, eukaryotic
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Homologous_superfamily IPR037013 Glutathione synthase, substrate-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gss-201 (1)    Ensembl 2050
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gss No data available
MARKER RELATIONSHIPS
gss Contained in: [BAC] DKEY-78O15 (1) (order this)
gss Encodes: [EST] cb814 (1) (order this)
[cDNA] MGC:101574 (1), MGC:192835 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001006104 (1) 2005 nt
Genomic GenBank:CR318666 (1) 198176 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QGJ2 (1) 475 aa
Sequence Information (all 17)
ORTHOLOGY for gss ( Chr: 23 )
CITATIONS (33)