ZFIN ID: ZDB-GENE-041010-190
Gene Name: ORMDL sphingolipid biosynthesis regulator 3
Gene Symbol: ormdl3    Nomenclature History

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Previous Name: zgc:101654 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to be involved in cellular sphingolipid homeostasis; ceramide metabolic process; and negative regulation of ceramide biosynthetic process. Predicted to localize to SPOTS complex and endoplasmic reticulum. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3).
Genome Resources: Alliance (1),  Gene:450067 (1),  Ensembl(GRCz11):ENSDARG00000025555 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101654]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14287 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ormdl3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ormdl3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ceramide metabolic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function molecular_function (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript ormdl3-202 (1)    Ensembl 787
    mRNA ormdl3-201 (1)    Ensembl 1473
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ormdl3 No data available
    MARKER RELATIONSHIPS
    ormdl3 Contained in: [BAC] DKEY-29B5 (1) (order this)
    ormdl3 Encodes: [cDNA] MGC:101654 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001006087 (1) 1498 nt
    Genomic GenBank:CR388157 (1) 225145 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5XJR6 (1) 153 aa
    Sequence Information (all 10)
    ORTHOLOGY for ormdl3 ( Chr: 12 )
    CITATIONS (24)