ZFIN ID: ZDB-GENE-041010-165
Gene Name: ankyrin 2b, neuronal
Gene Symbol: ank2b    Nomenclature History

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Previous Names: ank2, zgc:101738 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have aspartic-type endopeptidase activity. Predicted to be involved in protein localization to T-tubule and regulation of cardiac muscle contraction. Predicted to localize to T-tubule. Is expressed in central nervous system; cranial ganglion; optic vesicle; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2).
Genome Resources: Alliance (1),  Gene:450043 (1),  Ensembl(GRCz11):ENSDARG00000043313 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:101738]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016184Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029381Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029382Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ank2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ankyrin-B-related cardiac arrhythmia Alliance Cardiac arrhythmia, ankyrin-B-related 600919
    Long QT syndrome 4 600919
    DISEASE ASSOCIATED WITH ank2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component T-tubule (more)
    Molecular Function aspartic-type endopeptidase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ank2b-201 (1)    Ensembl 1495
    ank2b-202 (1)    Ensembl 294
    ank2b-203 (1)    Ensembl 713
    ank2b-204 (1)    Ensembl 1401
    ank2b-205 (1)    Ensembl 11061
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ank2b No data available
    MARKER RELATIONSHIPS
    ank2b Contained in: [BAC] DKEY-14I8 (1) (order this), DKEY-210I1 (1) (order this)
    ank2b Encodes: [cDNA] MGC:101738 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001006063 (1) 1509 nt
    Genomic GenBank:CR354563 (1) 147943 nt
    Select Tool
    Polypeptide UniProtKB:A2BIB9 (1) 3538 aa
    Sequence Information (all 95)
    ORTHOLOGY for ank2b ( Chr: 7 )
    CITATIONS (25)