ZFIN ID: ZDB-GENE-041010-140
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Gene Name: claudin 5b
Gene Symbol: cldn5b    Nomenclature History

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Previous Name: zgc:103419

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Predicted to localize to the bicellular tight junction; integral component of membrane; and plasma membrane. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in cardiovascular system; retina; and ventral mesoderm. Orthologous to human CLDN5 (claudin 5).
Genome Resources: Alliance (1),  Gene:450023 (1),  Ensembl(GRCz11):ENSDARG00000014059 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 6 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [MGC:103419]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cldn5b N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cldn5b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cldn5b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process biological_process (more)
Cellular Component bicellular tight junction (more)
Molecular Function structural molecule activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017974 Claudin, conserved site
Family IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Family IPR006187 Claudin
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cldn5b-201 (1)    Ensembl 1647
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Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS
Addgene:p5Ecldn5bE1
Addgene:pMEcldn5bP1gfp
Addgene:pT2-cryR;cldn5bCE1-basEgfp
Addgene:pT2-cryR;cldn5bCE1-P1Egfp
Addgene:pT2-cryR;cldn5bP1Egfp
CONSTRUCTS WITH SEQUENCES FROM cldn5b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(fli1:EGFP-cldn5b) fli1 cldn5b,  EGFP Danio rerio 1 2
MARKER RELATIONSHIPS
cldn5b Contained in: [BAC] CH211-122A17 (1)
cldn5b Encodes: [cDNA] MGC:103419 (1), MGC:192214 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001006044 (1) 1621 nt
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Genomic GenBank:CR384089 (1) 92630 nt
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Polypeptide UniProtKB:F1R5J2 (1) 220 aa
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Sequence Information (all 13)
ORTHOLOGY for cldn5b ( Chr: 10 )
CITATIONS (40)