ZFIN ID: ZDB-GENE-041010-139
Gene Name: cathepsin Z
Gene Symbol: ctsz    Nomenclature History

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Previous Names: wu:fj81f10, zgc:103420

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Involved in angiogenesis. Predicted to localize to the extracellular space and lysosome. Is expressed in blood; cardiovascular system; intestinal bulb; macrophage; and yolk syncytial layer. Orthologous to human CTSZ (cathepsin Z).
Genome Resources: Alliance (1),  Gene:450022 (1),  Ensembl(GRCz11):ENSDARG00000043081 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31540 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ctsz N/A 1
    MO2-ctsz N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctsz HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ctsz VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component extracellular space (more)
    Molecular Function cysteine-type peptidase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR025661 Cysteine peptidase, asparagine active site
    Domain IPR000668 Peptidase C1A, papain C-terminal
    Family IPR033157 Cathepsin Z
    Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctsz-201 (1)    Ensembl 1632
    ctsz-202 (1)    Ensembl 429
    ncRNA ctsz-003 (1)    Ensembl 870
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctsz No data available
    MARKER RELATIONSHIPS
    ctsz Contained in: [BAC] CH211-122I22 (1)
    ctsz Encodes: [EST] fj81f10
    [cDNA] MGC:103420 (1), MGC:191242 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001006043 (1) 1407 nt
    Genomic GenBank:BX927257 (1) 133388 nt
    Select Tool
    Polypeptide UniProtKB:F1RDQ9 (1) 301 aa
    Sequence Information (all 15)
    ORTHOLOGY for ctsz ( Chr: 6 )
    CITATIONS (28)