ZFIN ID: ZDB-GENE-041010-117
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Gene Name: glutaryl-CoA dehydrogenase b
Gene Symbol: gcdhb    Nomenclature History

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Previous Names: gcdhl, zgc:103477

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have acyl-CoA dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase).
Genome Resources: Alliance (1),  Gene:450003 (1),  Ensembl(GRCz11):ENSDARG00000098831 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103477]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024269Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gcdhb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    glutaric acidemia I Alliance Glutaricaciduria, type I 231670
    DISEASE ASSOCIATED WITH gcdhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component mitochondrion (more)
    Molecular Function acyl-CoA dehydrogenase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR006089 Acyl-CoA dehydrogenase, conserved site
    Domain IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
    Domain IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
    Homologous_superfamily IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
    Domain IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
    Homologous_superfamily IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
    Homologous_superfamily IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gcdhb-201 (1)    Ensembl 1383
    Select Tool
    gcdhb-202 (1)    Ensembl 1198
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gcdhb No data available
    MARKER RELATIONSHIPS
    gcdhb Contained in: [BAC] DKEY-61N16 (1) (order this)
    gcdhb Encodes: [cDNA] MGC:103477 (1), MGC:191186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001006024 (1) 1555 bp
    Select Tool
    Genomic GenBank:AL935209 (1) 162012 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QB98 (1) 441 aa
    Select Tool
    Sequence Clusters UniGene:14829 (1)
    Sequence Information (all 18)
    ORTHOLOGY for gcdhb ( Chr: 3 )
    CITATIONS (22)