Gene

amt

ID
ZDB-GENE-041010-114
Name
aminomethyltransferase
Symbol
amt Nomenclature History
Previous Names
  • fc31f04
  • wu:fc31f04
  • wu:fd44b12
  • wu:fd54h12
  • zgc:103483
  • zgc:109741
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to localize to mitochondrion. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With amt Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
glycine encephalopathy Alliance Glycine encephalopathy 605899
Associated With amt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006222 Aminomethyltransferase, folate-binding domain
Domain IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
Family IPR006223 Glycine cleavage system T protein
Family IPR028896 Aminomethyltransferase-like
Homologous_superfamily IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Homologous_superfamily IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
Domain Details Per Protein
Protein Length Aminomethyltransferase, folate-binding domain Aminomethyltransferase-like Glycine cleavage system T protein Glycine cleavage T-protein, C-terminal barrel domain Glycine cleavage T-protein/YgfZ, C-terminal GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
UniProtKB:Q5XJA4 409
UniProtKB:A9C3Q7 409
UniProtKB:F6P1J6 264
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations