Gene

cul4b

ID
ZDB-GENE-041008-208
Name
cullin 4B
Symbol
cul4b Nomenclature History
Previous Names
  • im:7140950
  • im:7150765
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to DNA damage stimulus; and protein ubiquitination. Predicted to localize to Cul4B-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 2 from Ando et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cul4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic X-linked intellectual disability Cabezas type Alliance Mental retardation, X-linked, syndromic 15 (Cabezas type) 300354
Associated With cul4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016157 Cullin, conserved site
Domain IPR001373 Cullin, N-terminal
Domain IPR016158 Cullin homology domain
Domain IPR019559 Cullin protein, neddylation domain
Family IPR033044 Cullin-4B
Homologous_superfamily IPR016159 Cullin repeat-like-containing domain superfamily
Homologous_superfamily IPR036317 Cullin homology domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Cullin-4B Cullin, conserved site Cullin homology domain Cullin homology domain superfamily Cullin, N-terminal Cullin protein, neddylation domain Cullin repeat-like-containing domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1R029 849
UniProtKB:F8W428 864
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations