ZFIN ID: ZDB-GENE-041008-208
Gene Name: cullin 4B
Gene Symbol: cul4b    Nomenclature History

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Previous Names: im:7140950, im:7150765

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to DNA damage stimulus; and protein ubiquitination. Predicted to localize to Cul4B-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B).
Genome Resources: Alliance (1),  Gene:560313 (1),  Ensembl(GRCz11):ENSDARG00000060510 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7140950]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7150765]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2747 Point Mutation Unknown Premature Stop ENU
sa14313 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19087 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cul4b N/A 1
    MO2-cul4b N/A 2
    PHENOTYPE
    Data: Fig. 2 from Ando et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH cul4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    syndromic X-linked intellectual disability Cabezas type Alliance Mental retardation, X-linked, syndromic 15 (Cabezas type) 300354
    DISEASE ASSOCIATED WITH cul4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ubiquitin-dependent protein catabolic process (more)
    Cellular Component cullin-RING ubiquitin ligase complex (more)
    Molecular Function ubiquitin protein ligase binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cul4b-202 (1)    Ensembl 4111
    ncRNA cul4b-002 (1)    Ensembl 797
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cul4b No data available
    MARKER RELATIONSHIPS
    cul4b Contained in: [BAC] DKEY-15N5 (1) (order this)
    cul4b Encodes: [EST] IMAGE:7140950 (1), IMAGE:7150765 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001122844 (1) 4139 nt
    Genomic GenBank:BX004980 (1) 159333 nt
    Select Tool
    Polypeptide UniProtKB:F8W428 (1) 864 aa
    Sequence Information (all 8)
    ORTHOLOGY for cul4b ( Chr: 14 )
    CITATIONS (19)