ZFIN ID: ZDB-GENE-041008-175
Gene Name: filamin C, gamma b (actin binding protein 280)
Gene Symbol: flncb    Nomenclature History

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Previous Names: im:7139256, sot, wu:fc02d03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have actin binding activity. Involved in several processes, including cilium assembly; muscle cell cellular homeostasis; and sarcomere organization. Used to study autosomal dominant polycystic kidney disease and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in distal muscular dystrophy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Is expressed in several structures, including adaxial cell; optic vesicle; primitive heart tube; retina; and skeletal muscle cell. Orthologous to human FLNC (filamin C).
Genome Resources: Alliance (1),  Gene:570288 (1),  Ensembl(GRCz11):ENSDARG00000018820 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 5 figures (4 images) from Thisse et al., 2004 [IMAGE:7139256]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011140Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p1cpej Point Mutation Exon 30 Premature Stop ENU
    sa5246 Point Mutation Unknown Splice Site ENU
    sa6929 Point Mutation Unknown Splice Site ENU
    sa7556 Point Mutation Unknown Missense ENU
    sa11171 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11278 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12735 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15601 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20216 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20217 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26231 Point Mutation Unknown Premature Stop ENU
    sa31379 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33399 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33400 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38425 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40229 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40230 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45167 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-flncb N/A 1
    MO2-flncb N/A 3
    MO3-flncb N/A 1
    MO4-flncb N/A 1
    DISEASE ASSOCIATED WITH flncb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    distal muscular dystrophy 4 Alliance Myopathy, distal, 4 614065
    hypertrophic cardiomyopathy 26 Alliance Cardiomyopathy, familial restrictive 5 617047
    myofibrillar myopathy 5 Alliance Myopathy, myofibrillar, 5 609524
    Cardiomyopathy, familial hypertrophic, 26
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component cellular_component (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
    Domain IPR001715 Calponin homology domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR014756 Immunoglobulin E-set
    Homologous_superfamily IPR036872 CH domain superfamily
    Repeat IPR001298 Filamin/ABP280 repeat
    Repeat IPR017868 Filamin/ABP280 repeat-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flncb-001 (1) 7873
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM flncb No data available
    MARKER RELATIONSHIPS
    flncb Contained in: [BAC] CH211-284B12, DKEY-30O6 (order this)
    flncb Encodes: [EST] fc02d03, IMAGE:7139256 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009300205 (1)
    Genomic GenBank:BX470230 (1) 173564 nt
    Select Tool
    Polypeptide UniProtKB:F1QL44 (1) 2773 aa
    Sequence Information (all 40)
    ORTHOLOGY for flncb ( Chr: 4 )
    CITATIONS (35)