Gene

flncb

ID
ZDB-GENE-041008-175
Name
filamin C, gamma b (actin binding protein 280)
Symbol
flncb Nomenclature History
Previous Names
  • im:7139256
  • sot
  • wu:fc02d03
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable actin binding activity. Acts upstream of or within several processes, including locomotory behavior; muscle cell cellular homeostasis; and organelle assembly. Is expressed in several structures, including adaxial cell; optic vesicle; primitive heart tube; retina; and skeletal muscle cell. Used to study autosomal dominant polycystic kidney disease and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in distal muscular dystrophy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flncb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
distal muscular dystrophy 4 Alliance Myopathy, distal, 4 614065
hypertrophic cardiomyopathy 26 Alliance Cardiomyopathy, familial hypertrophic, 26 617047
hypertrophic cardiomyopathy 26 Alliance Cardiomyopathy, familial restrictive 5 617047
myofibrillar myopathy 5 Alliance Myopathy, myofibrillar, 5 609524
Associated With flncb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001715 Calponin homology domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036872 CH domain superfamily
Repeat IPR001298 Filamin/ABP280 repeat
Repeat IPR017868 Filamin/ABP280 repeat-like
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily Filamin/ABP280 repeat Filamin/ABP280 repeat-like Immunoglobulin E-set Immunoglobulin-like fold
UniProtKB:Q5CZV6 218
UniProtKB:F1QL44 2773
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations