Gene

top2b

ID
ZDB-GENE-041008-136
Name
DNA topoisomerase II beta
Symbol
top2b Nomenclature History
Previous Names
  • im:7138121 (1)
  • si:dkey-98n4.1
  • wu:fc38e02
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in axon target recognition; retina layer formation; and retinal ganglion cell axon guidance. Predicted to localize to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex and nucleus. Is expressed in brain; eye; immature eye; and pharyngeal arch 3-7. Orthologous to human TOP2B (DNA topoisomerase II beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With top2b Human Ortholog
No data available
Associated With top2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018522 DNA topoisomerase, type IIA, conserved site
Domain IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
Domain IPR003594 Histidine kinase/HSP90-like ATPase
Domain IPR006171 TOPRIM domain
Domain IPR012542 DTHCT
Domain IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
Domain IPR031660 C-terminal associated domain of TOPRIM
Domain IPR034157 DNA topoisomerase 2, TOPRIM domain
Family IPR001241 DNA topoisomerase, type IIA
Family IPR028467 DNA topoisomerase II-beta
Homologous_superfamily IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
Homologous_superfamily IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
Homologous_superfamily IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
Homologous_superfamily IPR013760 DNA topoisomerase, type IIA-like domain superfamily
Homologous_superfamily IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Domain Details Per Protein
Protein Length C-terminal associated domain of TOPRIM DNA topoisomerase 2, TOPRIM domain DNA topoisomerase II-beta DNA topoisomerase, type IIA DNA topoisomerase, type IIA, conserved site DNA topoisomerase, type IIA-like domain superfamily DNA topoisomerase, type IIA, subunit A/C-terminal DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta DNA topoisomerase, type IIA, subunit B, C-terminal DNA topoisomerase, type IIA, subunit B, domain 2 DTHCT Histidine kinase/HSP90-like ATPase Histidine kinase/HSP90-like ATPase superfamily Ribosomal protein S5 domain 2-type fold Ribosomal protein S5 domain 2-type fold, subgroup TOPRIM domain Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
UniProtKB:A3KNQ9 145
UniProtKB:Q1LUT2 1618
UniProtKB:I3ITD0 139
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations