ZFIN ID: ZDB-GENE-041008-136
Gene Name: DNA topoisomerase II beta
Gene Symbol: top2b    Nomenclature History

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Previous Names: im:7138121 (1), si:dkey-98n4.1, wu:fc38e02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in axon target recognition; retina layer formation; and retinal ganglion cell axon guidance. Predicted to localize to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex and nucleus. Is expressed in brain; eye; immature eye; and pharyngeal arch 3-7. Orthologous to human TOP2B (DNA topoisomerase II beta).
Genome Resources: Alliance (1),  Gene:569877 (1),  Ensembl(GRCz11):ENSDARG00000034195 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138121]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020645Tg Transgenic Insertion Unknown Unknown DNA
la020647Tg Transgenic Insertion Unknown Unknown DNA
la028010Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s380 Point Mutation Acceptor Splice Site of Exon 11 Frameshift, Premature Stop ENU
    sa11711 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23498 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-top2b N/A 1
    DISEASE ASSOCIATED WITH top2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH top2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon target recognition (more)
    Cellular Component DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (more)
    Molecular Function DNA-dependent ATPase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA top2b-201 (1)    Ensembl 5653
    top2b-202 (1)    Ensembl 856
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM top2b No data available
    MARKER RELATIONSHIPS
    top2b Contained in: [BAC] CH211-185O22 (1), DKEY-98N4 (1) (order this)
    top2b Encodes: [EST] fc38e02 (1), IMAGE:7138121 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045191 (1) 4857 nt
    Genomic GenBank:CR391921 (1) 132783 nt
    Select Tool
    Polypeptide UniProtKB:Q1LUT2 (1) 1618 aa
    Sequence Information (all 17)
    ORTHOLOGY for top2b ( Chr: 19 )
    CITATIONS (32)