Gene

grin2da

ID
ZDB-GENE-041008-124
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
Symbol
grin2da Nomenclature History
Previous Names
  • NR2D.2 (1)
  • im:7137805 (1)
  • si:dkey-154b17.1
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Is expressed in presumptive neural retina; retina; and somite. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin2da Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 46 Alliance Epileptic encephalopathy, early infantile, 46 617162
Associated With grin2da Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor
Domain IPR001828 Receptor, ligand binding region
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family IPR001508 Ionotropic glutamate receptor, metazoa
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Ionotropic glutamate receptor Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:Q5BLC6 553
UniProtKB:I3NI77 1916
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations