| ZFIN ID: ZDB-GENE-041008-108 |
| Gene Name: | X-ray repair complementing defective repair in Chinese hamster cells 5 | |||||||||||||
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| Gene Symbol: | xrcc5 Nomenclature History |
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Attributions
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| Previous Names: | im:7137560, Ku80 (1), si:ch211-239d11.4 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 9 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to contribute to double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to localize to Ku70:Ku80 complex and nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Orthologous to human XRCC5 (X-ray repair cross complementing 5). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:449848 (1), Ensembl(GRCz11):ENSDARG00000099298 (1) | |||||||||||||
| All Expression Data: | 3 figures from 2 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137560] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (more) |
| Cellular Component | Ku70:Ku80 complex (more) |
| Molecular Function | ATP binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA | ottdart00000062217 (1) | 808 |
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xrcc5-201
(1)
|
2493 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM xrcc5
No data available
MARKER RELATIONSHIPS
| xrcc5 Contained in: | [BAC] CH211-239D11 (1), CH211-241J8 (1) |
| xrcc5 Encodes: |
[EST]
IMAGE:7137560 (1)
[cDNA] MGC:136642 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001017360 (1) | 2540 nt |
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| Genomic | GenBank:CR339053 (1) | 154689 nt | |
| Polypeptide | UniProtKB:A0A0R4IB13 (1) | 727 aa |
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ORTHOLOGY for xrcc5 (
Chr:
9
)
CITATIONS (35)