Gene
xrcc5
- ID
- ZDB-GENE-041008-108
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 5
- Symbol
- xrcc5 Nomenclature History
- Previous Names
-
- im:7137560
- Ku80 (1)
- si:ch211-239d11.4
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Is predicted to contribute to double-stranded DNA binding activity. Involved in DNA metabolic process and cellular response to ionizing radiation. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137560 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR005160 | Ku70/Ku80 C-terminal arm |
| Domain | IPR005161 | Ku70/Ku80, N-terminal alpha/beta |
| Domain | IPR006164 | Ku70/Ku80 beta-barrel domain |
| Domain | IPR014893 | Ku, C-terminal |
| Family | IPR024193 | Ku80 |
| Homologous_superfamily | IPR016194 | SPOC-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| Homologous_superfamily | IPR036494 | Ku, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Ku70/Ku80 beta-barrel domain | Ku70/Ku80 C-terminal arm | Ku70/Ku80, N-terminal alpha/beta | Ku80 | Ku, C-terminal | Ku, C-terminal domain superfamily | SPOC-like, C-terminal domain superfamily | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IB13
|
727 | |||||||||
|
UniProtKB:Q5FY48
|
727 | |||||||||
|
UniProtKB:A4FUM7
|
727 |
Interactions and Pathways
No data available
Plasmids
No data available