ZFIN ID: ZDB-GENE-041008-108
Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Gene Symbol: xrcc5    Nomenclature History

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Previous Names: im:7137560, Ku80 (1), si:ch211-239d11.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to contribute to double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to localize to Ku70:Ku80 complex and nuclear chromosome, telomeric region. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
Genome Resources: Alliance (1),  Gene:449848 (1),  Ensembl(GRCz11):ENSDARG00000099298 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137560]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-xrcc5 N/A 3
MO2-xrcc5 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH xrcc5 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH xrcc5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (more)
Cellular Component Ku70:Ku80 complex (more)
Molecular Function ATP binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ottdart00000062217 (1) 808
xrcc5-201 (1)    Ensembl 2493
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM xrcc5 No data available
MARKER RELATIONSHIPS
xrcc5 Contained in: [BAC] CH211-239D11 (1), CH211-241J8 (1)
xrcc5 Encodes: [EST] IMAGE:7137560 (1)
[cDNA] MGC:136642 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001017360 (1) 2540 nt
Genomic GenBank:CR339053 (1) 154689 nt
Select Tool
Polypeptide UniProtKB:A0A0R4IB13 (1) 727 aa
Sequence Information (all 17)
ORTHOLOGY for xrcc5 ( Chr: 9 )
CITATIONS (35)