Gene
xrcc5
- ID
- ZDB-GENE-041008-108
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 5
- Symbol
- xrcc5 Nomenclature History
- Previous Names
-
- im:7137560
- Ku80 (1)
- si:ch211-239d11.4
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of Ku70:Ku80 complex. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137560 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR005160 | Ku70/Ku80 C-terminal arm |
| Domain | IPR005161 | Ku70/Ku80, N-terminal alpha/beta |
| Domain | IPR006164 | Ku70/Ku80 beta-barrel domain |
| Domain | IPR014893 | Ku, C-terminal |
| Family | IPR024193 | Ku80 |
| Homologous_superfamily | IPR016194 | SPOC-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| Homologous_superfamily | IPR036494 | Ku, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ku70/Ku80 beta-barrel domain | Ku70/Ku80 C-terminal arm | Ku70/Ku80, N-terminal alpha/beta | Ku80 | Ku, C-terminal | Ku, C-terminal domain superfamily | SPOC-like, C-terminal domain superfamily | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IB13 | InterPro | 727 |
Interactions and Pathways
No data available
Plasmids
No data available