ZFIN ID: ZDB-GENE-041001-172
Gene Name: myelin transcription factor 1-like, a
Gene Symbol: myt1la    Nomenclature History

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Previous Name: si:dkey-260n20.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 39. Orthologous to human MYT1L (myelin transcription factor 1 like).
Genome Resources: Alliance (1),  Gene:559505 (1),  Ensembl(GRCz11):ENSDARG00000008209 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013851Tg Transgenic Insertion Unknown Unknown DNA
la021537Tg Transgenic Insertion Unknown Unknown DNA
la028241Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028242Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10388 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11068 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23731 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37064 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myt1la
    1
    MO1-myt1la N/A 1
    MO2-myt1la N/A 1
    PHENOTYPE
    Data: Fig. 5 from Blanchet et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH myt1la HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 39 Alliance Mental retardation, autosomal dominant 39 616521
    DISEASE ASSOCIATED WITH myt1la VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function zinc ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myt1la-201 (1)    Ensembl 4144
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myt1la No data available
    MARKER RELATIONSHIPS
    myt1la Contained in: [BAC] DKEY-47G2 (1) (order this), DKEY-260N20 (1) (order this)
    myt1la Encodes: [cDNA] MGC:198353 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044899 (1) 3936 nt
    Genomic GenBank:BX248326 (1) 182841 nt
    Select Tool
    Polypeptide UniProtKB:Q5TZG3 (1) 1257 aa
    Sequence Information (all 23)
    ORTHOLOGY for myt1la ( Chr: 20 )
    CITATIONS (27)